Glycolic Acid + Bakuchiol
Safe to Combine
These ingredients are generally well-tolerated together with no special precautions needed.
Bakuchiol is a plant-based retinol alternative that pairs safely with glycolic acid without causing pH conflicts or excessive irritation.
What the Research Says
Bakuchiol is a meroterpene derived from the seeds and leaves of the Psoralea corylifolia (babchi) plant. It has gained significant attention in dermatology as a functional analog of retinol - clinical trials have demonstrated that it stimulates collagen production, reduces fine lines, and improves skin firmness and pigmentation through retinol-like gene expression pathways. Crucially, unlike retinol, bakuchiol does not cause photosensitivity or the characteristic "retinization" period of peeling and irritation that makes combining retinoids with glycolic acid so challenging.
This absence of photosensitivity and lower irritation potential makes bakuchiol an ideal partner for glycolic acid. Where retinol and glycolic acid together create a cumulative irritation burden that requires careful scheduling and slow introduction, bakuchiol can be layered with glycolic acid in the same routine without the same risk of barrier disruption. Both ingredients promote cell turnover and collagen synthesis through complementary mechanisms - glycolic acid via surface exfoliation and bakuchiol via retinoid receptor activation - delivering anti-aging benefits without doubling the side effects.
Bakuchiol also has inherent anti-inflammatory and antioxidant properties, which can help soothe the mild irritation that glycolic acid sometimes causes. For individuals who want the benefits of a retinol-plus-glycolic-acid routine but cannot tolerate actual retinoids, bakuchiol provides a well-tolerated alternative with growing clinical support.
Timing & How to Use
Can be used in the same routine as glycolic acid. Apply glycolic acid first, allow it to absorb for a few minutes, then apply bakuchiol serum. Both can be used in the evening routine. Unlike retinol, bakuchiol does not require alternating nights with glycolic acid.
Practical Tips
- 1Bakuchiol does not cause photosensitivity, but you should still wear sunscreen daily when using glycolic acid
- 2Look for products with 0.5-2% bakuchiol concentration for clinically meaningful results
- 3This combination is excellent for pregnancy or breastfeeding when retinoids are contraindicated
- 4Bakuchiol is stable in formulation and does not degrade at the low pH of glycolic acid products
References
- Dhaliwal S, et al. Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. Br J Dermatol. 2019;180(2):289-296.
- Chaudhuri RK, Bojanowski K. Bakuchiol: A retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. Int J Cosmet Sci. 2014;36(3):221-230.
- Bluemke A, et al. Effect of a bakuchiol-containing moisturizer on facial skin photoaging: A randomized, double-blind, vehicle-controlled study. J Cosmet Dermatol. 2022;21(12):6636-6645.