Glycolic Acid + Squalane
Safe to Combine
These ingredients are generally well-tolerated together with no special precautions needed.
Squalane is a lightweight, non-comedogenic oil that counteracts glycolic acid dryness without clogging pores or interfering with exfoliation.
What the Research Says
Squalane is the hydrogenated (stabilized) form of squalene, a lipid that human skin naturally produces as part of its sebum. It makes up approximately 12% of the skin's surface lipids and plays a key role in maintaining moisture, flexibility, and barrier integrity. Because squalane is bioidentical to a component the skin already recognizes, it is exceptionally well-tolerated - non-comedogenic, non-irritating, and suitable for all skin types including acne-prone and sensitive skin.
Glycolic acid exfoliation can temporarily increase transepidermal water loss and strip surface lipids, leaving the skin feeling tight and dry. Squalane directly addresses this by replenishing the lipid layer without the heaviness of traditional oils. Its molecular structure allows it to absorb quickly and sit within the skin's natural lipid matrix rather than forming a greasy film on the surface. This makes it an excellent post-glycolic-acid treatment that restores comfort without occluding pores or trapping dead cells.
Unlike squalene (the unsaturated precursor), squalane is fully hydrogenated and oxidatively stable - it will not go rancid, break down under light exposure, or interact with glycolic acid's low pH. This stability makes it reliable in multi-step routines where it might sit on the skin alongside acid residue.
Timing & How to Use
Apply squalane after glycolic acid has fully absorbed, typically as one of the last steps in your evening routine. It can be used alone as a lightweight moisturizer or mixed into your existing moisturizer. Works well in both morning and evening routines.
Practical Tips
- 1A few drops of squalane are sufficient - it spreads easily and a little goes a long way
- 2Squalane can be mixed directly into other serums or moisturizers for added slip and hydration
- 3Plant-derived squalane (from olives or sugarcane) is chemically identical to shark-derived versions but is sustainable and cruelty-free
- 4If glycolic acid leaves your skin feeling tight, applying squalane within minutes of the acid can restore comfort quickly
References
- Huang ZR, et al. Biological and pharmacological activities of squalene and related compounds: Potential uses in cosmetic dermatology. Molecules. 2009;14(1):540-554.
- Kim SK, Karadeniz F. Biological importance and applications of squalene and squalane. Adv Food Nutr Res. 2012;65:223-233.
- Pappas A. Epidermal surface lipids. Dermatoendocrinol. 2009;1(2):72-76.
